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1 Introduction Fatigue is a common chronic cross-diagnostic symptom ( In CFS, fatigue of unknown origin is a hallmark diagnostic feature ( In hypothyroidism, about 15 20% of patients report fatigue or brain fog even after correction of thyroxine levels to normal with levothyroxine ( L-carnitine supplementation has been suggested to reduce fatigue in both hypothyroidism (30, 31)

[DOI] [PubMed] [Google Scholar] 67.Lublin F.D., Reingold S.C

Ann N Y Acad Sci 939:162178 Calabrese V, Ravagna A, Colombrita C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM (2005) Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2