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Hydroperoxides (ROOH) Hydroperoxides are unstable compounds formed via lipid (LOOH), protein (POOH), and DNA oxidation, originating primarily from three hepatic sources: (1) electron leakage from the mitochondrial electron transport chain (particularly Complex I/III), (2) ROS-generating activity of CYP2E1, and (3) the NOX enzyme family (predominantly NOX4)

"The systemic availability of oral glutathione"

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[DOI] [PubMed] [Google Scholar] 783

Arginase 1 (cytosolic isoform) expression in MDSCs is also important for the suppressive function of these cells, restraining Teffs-mediated antitumor immunity and promoting both Teffs cell death and Tregs suppressive effects [85, 86]