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coli MG1655, respectively to construct the recombinant strains ET00 and ET01 (Table 1)

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Boland R, Vasconsuelo A, Milanesi L, Ronda AC, de Boland AR

The increased efflux of FFAs from adipose tissue to lipid-sensitive tissues (such as liver and skeletal and cardiac muscle) increases serine phosphorylation of IRSs

The HIF-1-regulated genes included vascular endothelial growth factor (VEGF), glucose transporters (GLUTs), pyruvate dehydrogenase kinase 1 (PDK1), erythropoietin, insulin-like growth factor 2 (IGF-2), transforming growth factor , B-cell lymphoma 2 (BCL-2), BCL-2 interacting protein 3 (BNIP3), and heme oxygenase-1 (HO-1) 23

Other signaling pathways involved in cell dysfunction mTOR can phosphorylate AGC family of protein kinases, regulating cell survival and proliferation