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This alteration is linked to a low protein expression of the canalicular bile salt transporter, Bsep.185 A posttranscriptional mechanism seems to be involved, since no changes in the levels of Bsep mRNA has been observed.186 On the other hand, mRNA levels of the bile saltuptake systems, Ntcp and Oatps (Oatp1a1 and Oatp1a4 isoforms), are decreased, although this has not been confirmed at the protein level.186 Apart from alterations in bile salt hepatic handling, Long-Evans Cinnamon rats have hyperbilirubinaemia,184,187 and impairment of the excretion of the Mrp2 substrate, BSP.188 If these alterations involve changes in the expression of Mrp2, the rate-limiting step of both bilirubin and BSP hepatic handling, this would be nontranscriptional, since Mrp2 mRNA levels are normal in these rats.186 Alternatively, the above-mentioned transcriptional downregulation of Oatps, which also transport nonbile salt organic anions such as BSP and bilirubin, may be a contributing factor

Moreno-Torres M

A small drop of acetone is applied directly to the hindpaw of the tested animals, which induces evaporative cooling on the hindpaw skin to an innocuous temperature between 15 and 21C (Warncke et al., 2021)

In cancer cells, glucose is converted into fatty acids by the enzymatic action of fatty acid synthase

Along with its beneficial effect on pancreatitis, a positive influence of NaBPC157 on gastric and duodenal lesion course in bile duct ligated rats was noted in both pre- and post-treatment applications

Samples were then boiled for one hour at 95 C and centrifuged at 3000 g for 10 min