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This receptor-mediated transcriptional regulation represents a primary mechanism by which the exposome dynamically modulates CYP450 enzyme activity, thereby profoundly impacting drug metabolism and response

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T., Shahwan, M., & Aatif, M

Funding The Authors did not receive any specific grant for this research from funding agencies in the public, commercial or not-for-profit sectors

Another critical enzyme of PPP, 6-phosphogluconate dehydrogenase (6PGD), is upregulated in ATC and inhibition of 6PGD is proven to disrupt the doxorubicin-resistant situations in ATC cells [95]

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