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A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]

Furthermore, by binding with heavy metals, pesticides, and metabolic byproducts, glutathione reduces the liver's toxic load, protecting it from damage

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Mycotoxins, such as aflatoxins, ochratoxins, and fumonisins, are toxic metabolites produced by various fungi that pose serious health risks to humans and animals
[DOI] [PubMed] [Google Scholar] 42.Vamsi E.B., Devatha C

Low glutathione levels can potentially cause increased fat storage and fatty liver disease
