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doi: 10.1002/advs.202404073 44 WangYHuangXLuoGXuYDengXLinYet al

However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs

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Fact: High doses of poorly absorbed supplements are less effective than smaller, highly bioavailable doses that actually reach the cells

Therefore, we set out to genetically inactivate GSH biosynthesis ( GCLM ) by CRISPR/Cas9 in HCT116 cells (Supplementary Fig

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