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Injury Recovery Models Controlled injury models (e.g., tendon laceration, muscle contusion) allow measurement of recovery timelines and functional endpoints

Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy
Essence of ASH

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Most ROS are generated by the ETC during electron transport

Both the oxidation of nutrients in the mitochondria and the oxidation of nascent proteins in the ER generate toxic reactive oxygen species (ROS): in the mitochondria by electron leakage during oxidative phosphorylation (Murphy, 2009), and in the ER by catalysis of disulfide bond formation by ER oxidoreductase (ERO1) (Higa & Chevet, 2012)
