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Response: Consider whether simpler protocols might actually work better

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The underlying molecular mechanisms governing these changes and how NP cells can adopt a fibrotic phenotype require further investigation

Therefore, we speculate that two different metal elements such as Zn and Cu may be doped into mesoporous silica for dual ion delivery, and the delivery of quercetin-loaded Zn/Cu dual-doped mesoporous silica nanoparticles to the dermal region of the skin through microneedles can theoretically enable the active ingredients to exert long-term therapeutic effects in the dermal layer of the skin