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Fibrosis of bladder is well-observed in substance-induced cystitis, such as ketamine and cyclophosphamide, or radiation cystitis

[DOI] [PMC free article] [PubMed] [Google Scholar] 255.Nesti L, Pugliese NR, Sciuto P, Natali A

This increased expression of SOD1 appears to increase cell proliferation and metastasis, potentially by facilitating cell cycle progression and inhibiting apoptotic processes

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Pediatr Res 19 : 12981304

It is, in addition, a significant contributor to the burden of autoimmune diseases