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For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush (Guo et al., 2022)

Lycopene and EGCG can improve memory and restore glutathione system functionality despite the reduced glutathione levels [155]

Functional coupling of thromboxane A synthase (TXAS) and PGD synthase (PGDS) with COX1, which all partially co-localize to the ER, has been shown to preferentially produce the eicosanoids thromboxane A2 (TxA 2 ) and PGD 2 during short-term stimulation of rat peritoneal macrophages 36

The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group