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Therefore, previous researchers have employed the expression levels of 41 genes associated with glutamine metabolism to establish Glutamine Metabolism Scoring (GMScore) for assessing glutamine metabolism activity and predicting the prognosis of HCC, as well as the response to immune checkpoint inhibitor (ICI) therapy ( 2.3 Lipid metabolism Numerous studies have consistently demonstrated that a prominent hallmark of cancer cell metabolism involves the remodeling of lipid metabolism, encompassing fatty acid transportation, de novo lipid synthesis, storage within lipid droplets, and -oxidation

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FBDD has the advantages of a more efficient sampling of chemical space with fewer compounds and higher hit rates 85,86

10.1371/journal.pone.0177106 130

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For another type of cancer stem cells that is often mentioned to be similar to DTP, the drug resistance of DTP is a significant feature that cancer stem cells cannot have
