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Women and Hormonal Considerations Women may have specific considerations regarding both supplements

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RW, LW and YZ wrote the manuscript

Mechanistic studies indicate that TMAO can stimulate hepatocytes to release exosomes that are taken up by vascular endothelial cells, inducing expression of inflammatory cytokines (including IL-6, MCP-1, and TNF-), activating NF-B signaling, increasing endothelial cell apoptosis, and impairing endothelium-dependent vasodilation [116]

doi: 10.3233/NPM-210774, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 50.Lamhonwah AM, Bari I, Lamhonwah J, Grubi M, Tein I