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Next-generation compounds improve chemistry rather than biology: IKE increases potency and stability and PE increases aqueous solubility and exposure, yet both remain system Xc inhibitors and therefore retain the same on-target risk

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Lan, X., Chen, M., He, X., Gao, S

Among its known binding partners are E3 ligases TRIM27 and RNF41, and the deubiquitinases USP7 and USP8, which it recruits to regulate the ubiquitination and stability of diverse targets (Tacer and Potts, 2017

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