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Odo/Tanabe/Yamauchi : A Pilot Clinical Trial on L-Carnitine Supplementation in Combination with Motivation Training: Effects on Weight Management in Healthy Volunteers

Finally, adherence to MD seems to be easier than to other diets (e.g., HCD), which has been demonstrated by the recent CORDIOPREV study reporting adherence to the MD in 7 of 8 patients over a period of 7 years, given that patients are supported by dieticians [94]

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Specifically, in retinoic-acid osteoporotic mice, they can restructured the intestinal microbiota by increasing Firmicutes and Lactobacillus whereas decreasing Bacteroidetes and Bacteroides , and repair the damaged intestinal barrier by restoring goblet-cell density and upregulating tight junction proteins ZO-1 and Claudin-1, and consequently increased trabecular bone density and decreased osteoclast density [234]

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Increased FFAs can lead to hepatic lipotoxicity, generation of reactive oxygen, and damage to the mitochondrial membrane (52)