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up to 20% of adults face these, worsened by chronic stress activating the HPA axis via leaky gut

doi: 10.1016/j.stemcr.2017.05.026

Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins

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FPN activity is controlled by another protein produced in the liver called hepcidin, which reduces iron translocation by degrading FPN in the basement membranes of duodenocytes, macrophages, and hepatocytes, thereby lowering serum iron levels [18]

Seaver and Imlay, 2004)