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Comment: A commenter believed that our proposals merely add administrative burden without truly addressing program integrity

Dosage & Side Effects Combination Use in Non-Small Cell Lung Cancer (NSCLC) and Mesothelioma: The recommended dose of Pemetrexed injection is 500 mg/m2 administered as an intravenous (IV) infusion over 10 minutes on Day 1 of each 21-day cycle

This requires a higher level of complexity and risk management

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The 21-day window is set by TB-500's stability
