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Stage 3: Method-of-Use Patent Expansion (Years 5-20 from NDA) Post-approval clinical research frequently generates new uses for approved drugs, either as single agents in new indications or as components of combination regimens

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[DOI] [PubMed] [Google Scholar] 19.Martinez-Martin P., Rodriguez-Blazquez C., Kurtis M.M., Chaudhuri K.R., Group N.V

Disadvantages related to the use of synthetic materials include the risk of mesh adhesion, erosion of the esophageal wall, and extensive fibrosis resulting in the onset of troublesome dysphagia [38]