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In the classic db/db mouse model of metabolic fatty liver, oral administration of betaine can inhibit the interaction between forkhead box protein O6 and peroxisome proliferator-activated receptor gamma (PPAR), inhibit the expression of primary lipogenic genes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase, and reduce hepatic lipid accumulation (77, 78)

Much of the current evidence is preclinical (cell and animal studies), and human data is still limited

dAlessio, P., Moutet, M., Coudrier, E., Darquenne, S

We could even take a small diversion to the Apollonia ruins

On rest days, take your dose in the morning on an empty stomach

Brain Res 314:111