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Conflicting data are available on tDCS in combination with physical exercise [63,64,65]

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Alternatively, a bona fide L-lysine methyltransferase (K-NMT) yielding TML may be used

In addition, BCAA levels play a key role in interorgan metabolic crosstalk and, therefore, dysregulation of BCAA catabolism may play a significant role in several metabolic diseases [16]

In 2021, a single-center open-label clinical trial (N = 70 LOE2a) of LC supplementation (1000 mg/d) for 12 weeks in pediatric patients with NF showed that LC supplementation was safe and feasible, but it still needs to be confirmed in phase III clinical trials [70]