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Athletic animals which exercise regularly and strenuously have B-Group vitamin requirements far in excess of their less athletic counterparts

The logic is real but indirect: NAD+ falls with age, sirtuins depend on it, and propping up NAD+ is a recurring theme across the longevity peptides and compounds people study

doi: 10.1016/j.bcp.2004.05.042 Summary Keywords COVID-19, vitamin B12, epidrugs, chromatin remodeling, DNA methylation, epigenetic markings, inflammation, antiviral response Citation Cassiano LMG, Cavalcante-Silva V, Oliveira MS, Prado BVO, Cardoso CG, Salim ACM, Franco GR, DAlmeida V, Francisco SC and Coimbra RS (2023) Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic markings

Others alternate between them, using each for periods before switching
