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10.1038/nature07762 38 SuT.HuangY.WuD.WangS.JiangL

However, aggregate data and covariates of interest (eg, sex, disease severity) are not consistently reported across randomised clinical trials (RCTs).6 The use of individual patient data (IPD) has several advantages, such as it allows for the exploration of the relationship between treatment effects and patient-level characteristics, and it overcomes restrictions in using the information reported in the publication among others

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