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[11] [12] The combination might theoretically offer complementary cardiovascular support, but robust evidence is lacking, and neither is included in UK clinical guidelines for cardiovascular disease management or lipid modification

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The Fukuda criteria were established in 1991 and provided a comprehensive definition of chronic fatigue syndrome (CFS)

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Based on natural mutations 90, 91 , site-directed mutagenesis, 92 and synthetic peptide studies 93 , the C-terminal helix (Fig