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Introduction Nicotinamide N -methyltransferase (NNMT) catalyzes the transfer of a methyl group from the methyl donor S -adenosyl methionine (SAM) to nicotinamide (NAM) and other pyridine related compounds, producing S -adenosyl-l-homocysteine (SAH) and N1-methylnicotinamide (1-MNA) (Fig

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