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Blood 141 , 704712 (2023)

Mechanical obstruction of the vein through the rigid artery in the A/V crossing may result in turbulent blood flow producing damage to venous endothelium and intima media and the sequence of events leading to occlusion of the vein.12,14 The turbulent blood flow was confirmed by Christoffersen and Larsen in an investigation which analyzed the fluorescein angiograms of 250 patients with BRVO.17 Some studies have revealed an association between BRVO and hyperviscosity due to high hemotocrit.18,19Higher blood viscosity increases under conditions of low blood flow and erythrocyte aggregation.18Viscosity is mainly dependent upon the hematocrit (the greater the number of erythrocytes, the larger they aggregate) and plasma fibrinogen (required for aggregation to occur).20 Another discussed hematological disorder in the pathogenesis of BRVO is dysregulation of the thrombosis-fibrinolysis balance.21 The coagulation cascade including different blood factors results in the production of thrombin which converts circulating fibrinogen to fibrin

This gene mostly expresses in mitochondria [87] and takes part in mitochondrial transport, neuronal axon, and dendrite outgrowth, as well as proliferation, differentiation, and migration of neuronal cells

Tirzepatide weighs approximately 4,813 Daltons

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This test is a part of routine blood work and is particularly significant in diagnosing liver conditions