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As innate immune cellsincluding neutrophils, infiltrating macrophages, liver-resident macrophages (Kupffer cells), and DCsare key mediators of acute liver injury 23,24 , we analyzed their populations by flow cytometry (Supplementary Fig

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the Biobank cohort with n 500 000 (Reference Bycroft, Freeman and Petkova62) )

Results indicated that 279 natural compounds (62 terpenoids, 57 alkaloids, 52 flavonoids, 26 phenols, 19 phenylpropanoids, 9 steroids, 9 saponins, 8 quinonoids, 6 vitamins, and 31 others) can act on various mechanisms to improve UC, such as regulating gut microbiota and metabolites (Mechanisms I), protecting the intestinal mucosal barrier (Mechanisms II), regulating intestinal mucosal immune response (Mechanisms III), as well as the other mechanisms (cellular autophagy modulation and ferroptosis inhibition)