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Nutrition & Food Research 59 (7), 13641372

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Mechanism of Estrogens Effect on Melasma Estrogens, particularly estradiol (E2), estrone (E1), and estriol (E3), exhibit distinct molecular structures that influence their biological activity and bioavailability

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Oxidative stress and docosahexaenoic acid injury-induced downregulation of ferroptosis regulator acyl-CoA synthetase long-chain family member 4 (ACSL4), increased lipid peroxidation and decreased cell viability, and lead to ferroptosis in RPE (Neiteler et al., 2023)
