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preclinical safety evaluation found no genotoxicity, mutagenicity, or organ toxicity at tested doses

and R.T

[DOI] [PubMed] [Google Scholar] 191.Xu Y., Tu W., Sun D., Chen X., Ge Y., Yao S., Li B., Zhenbo Z., Liu Y

All experiments were repeated 3 times, and data were analyzed using Students t test (2 tailed) or 2-way ANOVA with multiple-comparisons post hoc tests, as appropriate

Additionally, endothelial cells exposed to oxHb show rearrangement of the actin cytoskeleton leading to disruption of the endothelial cell monolayer, intercellular gap formation and increased permeability of the monolayer, which did not occur upon heme exposure (Silva et al., 2009)

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