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All measurements were performed under strictly standardized conditions by the same certified skilled nutritionist and with the same device to avoid inter-observer and inter-device variability as reported in previous studies [36, 47, 48]

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L-carnitine and its acetylated derivatives (free carnitine, isovalerylcarnitine (C5), and octanoyl carnitine (C8)) were positively associated with ASD, and two (methylmalonyl carnitine (C4DC) and adipylcarnitine (C6DC)) were inversely associated with later diagnosis of ASD

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In severe CCDS, debilitating deficits are overt, significantly impairing basic functions and necessitating comprehensive support