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A stronger immune system

10.1016/j.brainres.2014.05.048 51 FineJ

Evidence within human hypertension is limited, with several indirect biomarkers that are purported to be indicators of gut permeability increased in participants with hypertension

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The diversity of available animal systems, from rodents suited for genetic manipulation and mechanistic exploration to large animal models such as dogs and nonhuman primates that offer closer anatomical, microbial, and immunological similarities to humans, provides a flexible framework in which earlystage hypotheses can be refined before being tested in more clinically relevant settings

These responses elevate the synthesis of superoxide dismutase (SOD), catalase, as well as key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione (GSH), thereby maintaining cellular redox homeostasis