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10.1016/j.jid.2020.11.006 [DOI] [PubMed] [Google Scholar] 102

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Vitamin C (Ascorbic Acid) Water-soluble free radical neutralizer Vitamin C stands as perhaps the most well-known antioxidant, functioning primarily in aqueous (water) environments both inside and outside cells

Cystine starvation has been shown to impede TNBC growth, which affects stem cell properties and chemotherapy resistance in TNBC (27), thereby promoting TNBC cell ferroptosis through activation of the general control nonderepessible 2-eukaryotic translation initiation factor 2 subunit 1-activating transcription factor 4-CHAC1 pathway through the specific cytosolic GSH degradation enzyme CHAC1 (28)

EOC accounts for ~8590% of all OC cases [3]

95% of remaining toxic metals are sequestered at B/B barrier by MT & GSH
