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In KRAS mutant CRC cell lines, levels of 5-hydroxymethylcytosine (a DNA methylation marker) were reduced, implying a decrease in DNA demethylation, which was reversed by the ablation of GC1 or KRAS mutant
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For example, Lee and colleagues reported that individuals with long COVID had higher levels of DNA methylation in certain genes involved in immune response and inflammation 11
doi: 10.1016/j.cell.2013.12.010 12 YangWSStockwellBR
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Available from: 106
