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Although these conclusions appeared to be justified based on the reported experiments, it again raised the issue of questionable neutropenia experiments111,115, and the findings contradicted previous data showing that IL-1 receptor-deficient mice were not protected123, that total elimination of Kupffer cells actually enhanced APAP-induced liver injury125,126, and that TLR9120,121 and TLR3127 are important for the pathophysiology

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Bioengineered BEMNs equipped with disease-specific ligand moieties and loaded with corresponding drugs represent a promising tool in nanomedicine, which can be used as a novel drug delivery system for a successful therapy of ASCVD

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