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A review published in Regulatory Toxicology and Pharmacology stated that the evidence of safety is strong at intakes up to 2000mg/day l-carnitine equivalents for chronic supplementation. The authors went on to note that taking higher levels had not shown any safety risks

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Ethics declarations Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Recent randomized trials and meta-analyses indicate modest reductions in blood pressure and minor improvements in lipid profiles when using standardized aged or freeze-dried garlic extracts ( 7 Discussion The evolving landscape of cardiovascular supplementation reflects a paradigm shift from empirical, population-wide approaches toward precision-based, biomarker-guided strategies

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Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B