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This leads to opening of the mitochondrial permeability transition pore (mPTP), a non-selective channel whose prolonged activation collapses the proton motive force, dissipates mitochondrial membrane potential (MMP), uncouples OXPHOS, and induces cristae remodeling and mitochondrial swelling

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It is important for both patients and prescribers to consider the pharmacokinetics and pharmacodynamics of glutathione when choosing this formulation

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