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7) Methylcobalamin is the active form of B12, which is easily absorbed and passes the blood brain barrier, making it an effective treatment for depression and mental fatigue

The broader NNMT-as-therapeutic-target hypothesis is supported by knockdown and knockout studies, but small-molecule pharmacological validation in humans is pending

(2023b)

However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

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Introducing synthetic peptides adds unpredictable variables