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However, hepatocytes do not strictly depend from ME-1 activity for NADPH synthesis: in ME-1 deficient mice, after an initial depletion, the GSH levels recover quickly and sensitivity to acetaminophen-induced liver injury was unaltered [26]

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Oravivattanakul S, Benchaya L, Wu G, Ahmed A, Itin I, Cooper S, Gostkowski M, Rudolph J, Appleby K, Sweeney P, Fernandez HH (2015) Dopamine Transporter (DaT) Scan Utilization in a Movement Disorder Center

doi: 10.1002/acr.20335 108 MillerFWAlfredssonLCostenbaderKHKamenDLNelsonLMNorrisJMet al

This interaction alters the shape of Keap1, forcing it to release its grip on Nrf2

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