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NAD+ raised higher NAD+ feeds mitochondrial energy production and switches on sirtuin enzymes

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Inhibition of Lipogenesis (The Pull): It inhibits Lipoprotein Lipase (LPL) and Acetyl-CoA Carboxylase (ACC), preventing the uptake of dietary fat and the synthesis of new triglycerides

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The third is duration and safety : short controlled studies in animals say almost nothing about what months or years of exposure would do in a human, which is precisely why the cycling section defaults to scheduled off periods rather than open-ended use