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However, excessive NRF2 signaling suppresses expression of critical microbicidal effector molecules in bone marrow-derived macrophages (BMMs), impairing mycobacterial clearance ( To determine whether Rv0801 influences the KEAP1-NRF2 axis, we first analyzed Nrf2 transcriptional activity in THP-1 macrophages infected with Rv0801 recombinant strains

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