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In heparin-induced thrombocytopenia, an immune reaction to heparin causes breakdown of platelets, releasing their contents and triggering widespread platelet activation, initiation of coagulation pathways, and a dramatic increase in risk of thrombosis

For CrossFit athletes dealing with systemic inflammation from chronic high-intensity training, this has a compounding benefit -- it does not just help the specific injury, it reduces the overall inflammatory load that slows recovery across the board

As the identified di-, hexa- and decadepsipeptides are not in line with the proposed biosynthetic assembly of three ready-made tetradepsipeptides 8,9 , these findings prompted us to ask whether the candidate depsipeptide esters are released from chemically unstable NRPS-bound PCP- S -ester or TE- O -ester intermediates of cereulide biosynthesis upon transesterification with ethanol, or are formed as artifacts by esterification of free depsipeptides or as cereulide degradation products released upon ethanolysis

M., Bonelli, M., Gadina, M

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