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While oral supplements are an option, they still have to go through the digestive system, where absorption issues can get in the way

Choline Choline is a water-soluble essential nutrient central to liver function and to the transport of fats out of the liver via VLDL particles

Mar 10 2013;31(8):1021-1028

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With such tight metal-protein affinities, off-rates to the hydrated state would be so slow as to exceed the lifetimes of proteins before thermodynamic equilibrium is approached: Associative ligand exchange overcomes this limitation