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In other words, the darkening of the skin is a visible sign that damage has already occurred

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Liu S., Schulze E., Baumeister R

Risk appeared larger among participants with lower baseline renal function, though interactions were not significant [15]

The run-in phase involved pre-weight-loss assessments (PRE), reducing energy intake to 60% of estimated weight-maintenance needs (to achieve weight loss of 12 2% relative to PRE body weight), stabilizing body weight after weight loss, and conducting assessments again at random assignment (START)