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Although there was a slight decrease in adiponectin (APN) levels, the difference did not reach statistical significance (Wang et al
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In fact, mild mitochondrial uncoupling, and the resulting increase in proton leak and decrease in mitochondrial membrane potential, has been previously suggested as a neuroprotective mechanism that cells utilize to prevent ROS formation by blocking the accumulation of electrons at early steps of the transport chain 60
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Safety and efficacy of a Na v 1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial
