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The resultant accumulation of labile iron intensifies oxidative stress via Fenton chemistry and ultimately renders dopaminergic neurons highly susceptible to ferroptosis (50)

However, computer-based modeling of both TKTL1 and TKTL2 indicates that they can form a similar binding pocket for TPP and xylulose-5 phosphate that is present in the TKT protein

1988;255:E513517

Energy & Mitochondrial Health Ever feel like your batteries are constantly running low

Under normal conditions, ROS are cleared from the cell by the action of superoxide dismutase (SOD), catalase (CAT), or glutathione peroxidase (GPx)

Sukenik S: Balneotherapy for rheumatic diseases at the Dead Sea area
