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Moreover, addition of CD38i to etomoxir treatment reinvigorated the IFN- production in noncontrollers, indicating that FAO blockade is reversible after additional treatment with CD38i, which may relate to increased levels of NAD + , which boost glycolysis (Figure 7K)

2 , 4862.e3 (2016)

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Structural analysis demonstrates how FOXO4-DRI exploits the unique architecture of senescent cells, where FOXO4 latches onto p53 and prevents it from executing its normal pro-apoptotic function

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