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In both a rat I/R model and hypoxia reoxygenation treated HK-2 cells, small nucleolar RNA host gene 14 (lncRNA SNHG14) expression was markedly upregulated

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10.1016/S1470-2045(17)30578-8 44 DongM.ZhangJ.HanX.HeJ.ZhengG.CaiZ

It is important to acknowledge that this thio-disulfide exchange based protein oligomerization inducer may face several challenges: (i) so far, it has only been tested on WDR5, and further exploration is needed to determine its applicability to other proteins, (ii) the disulfide bonds induced by WZ-1 are susceptible to cleavage under strong reducing conditions, so we need to develop strategies to ensure stable linkages that remain unaffected by intracellular environments, (iii) challenges persist in translating oligomerization inducers into viable drugs, primarily stemming from unforeseen oligomerization scenarios, such as excessive oligomerization and off-target proteins interactions

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However, the quality of post-mortem data can be variable, as GSH concentration in the brain drops rapidly after death and is affected by many pre- and post-mortem factors [19, 20]