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Stroke is an important risk factor for cognitive impairment, and the location, size, severity (Pendlebury and Rothwell, Most cognitive impairments (especially neurodegenerative cognitive disorders) are insidious in onset, slow in progression, and characterized by progressive worsening (Chinese Expert Consensus Committee on Brain Cognitive Health Management Chinese Journal of Health Management Editorial Committee, Lacunar cerebral infarction caused by CSVD accounts for 2550% of ischemic stroke (Tsai et al., 2013

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Furthermore, prior studies also reported that, prolonged use of HRT might raise the risk of developing certain type of cancer
