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JC-1 membrane potential The assay is based on the changes in electrochemical gradient across the mitochondrial membrane measured by membrane potential (MP)

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[DOI] [PubMed] [Google Scholar] 24.Cruciani R.A., et al

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however, only studies with EPA doses of at least 500 mg found significant improvements in hyperactive symptoms.43 Other meta-analyses also have found a significant association between EPA dose and efficacy.40 One review of 16 studies determined that those providing EFAs in the form of plant oils found no significant effects on ADHD symptoms.37 Overall, limitations in the research include variations in the number of participants, types and doses of EFAs, treatment lengths, and the use of plant oils in some control groups.36,37,51 In one small RCT (n=36), 100 mg of phosphatidylserine alone was given to children with ADHD for eight weeks, and the childrens symptoms improved (according to clinician ratings) over placebo.9 Overall, theres evidence for EFA supplements having small but significant effects on ADHD symptoms, although its difficult to determine specific recommendations due to the varying types and doses of supplements used in studies