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TIRFM analysis of vesicular trafficking and size TIRFM experiments were performed using a 100 (numerical aperture: 1.45) TIRF objective (Nikon Instruments) on a Nikon TE2000U microscope custom-modified with a TIRF illumination module as described previously 72

Amino acid metabolism in TC It cant be overemphasized how important amino acids are in both structural and functional aspects of normal cells as well as cancer cells

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10.1053/j.gastro.2015.06.009 159 YangY

Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8+ T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER

Specifically, IL-5 priming led Siglec-8 cross-linking to cause a loss of mitochondrial membrane potential and production of ROS inside the eosinophil, which in turn drove the cell into apoptosis through a caspase-independent mechanism (183)