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Aspiration during surgery: Tirzepatide slows stomach emptying, which may increase the risk of food or liquid entering the lungs during procedures using anesthesia or sedation

Signs you may need a booster include recurring fatigue, brain fog, irritability, or trouble sleeping, especially if the injections previously improved these symptoms

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Though it hasn't been proven, some researchers think that if you are often constipated and usually strain when you have a bowel movement, you may create enough pressure in the intestinal walls to weaken them and begin the development of diverticular pouches